Hard Rock Hotel & Casino Biloxi and Best Western Cypress Creek are among the best hotel options in Biloxi close to the city center. Where should I stay in Biloxi if I'd like to be close to the city center?.If you're trying to save money but still want to stay in a sophisticated hotel in Biloxi, you might want to think about booking a room at the Motel 6 Gulfport, Super 8 by Wyndham Ocean Springs Biloxi, Studio 6 Ocean Springs MS or the Motel 6 Biloxi - Ocean Springs, as they offer affordable rates. Where should I stay in Biloxi if I am on a budget?.